This autumn, we welcome another new student in our group: Christian Simonsson
My name is Christian Simonsson and I will be doing my master thesis here in the ISB-group. I am a 5th year engineering biology student with my master’s profile being Materials and Sensors in Biomedince. For my master’s thesis I wanted to do something a bit different from what I have been doing the last two years. Since my Bachelor’s project was on the topic of systems biology, and since I have an interest in modeling (in biology and physiology ), I was very pleased when I was given the opportunity to do my thesis here in the ISB group.
Adiponectin, which is a hormone released by mature adipocyte has been shown to have an important role in the development of type-2 diabetes. However, the precise underlying mechanisms for the production and release of such hormones in adipocytes are not fully understood. Therefore, an ongoing project in the ISB group has been to use mathematical modeling to describe the exocytosis of white adipocytes to predict adiponectin secretion, making it possible to quantify the exocytosis and endocytosis rates. An article on the subject was recently published by William Lövfors et al and in my project I will make use of the model presented in this article. The goal is to extend the model to also describe the experimental data for adiponectin secretion induced through the activation of beta-adrenergic signaling pathways upon extracellular adrenalin stimulation. Hopefully this might contribute to creating a more complete framework for understanding the regulation of this important metabolic hormone.