EventsPosted by ISB Group Fri, December 01, 2017 15:11:07
Last week some of us (Gunnar, William, Christian, Fredrik and Thea) went to Gothenburg to attend the Second Swedish Diabetes Summit. It’s a summit bringing together basic and clinical research.
We had a good time listening to some really interesting presentations with topics varying from treatment of metabolic diseases to artificial intelligence in health and diabetes. Gunnar was chairman for the session of AI and he and William also presented a poster each.
NewsPosted by ISB Group Thu, October 26, 2017 14:51:36
autumn, we welcome another new student in our group: Josef Grännö
Hello, my name is Josef, I study medicine, and
I’m here at ISB Group to do a project for my 6th semester.
My project is about glycemic management in
patients admitted to the intensive care unit. During my time here I will
compare different models that aim to be used as decision support systems to
help ICU staff maintain the patient’s glucose levels in optimal range. I
collaborate mainly with the GlucoSafe group that is based in Aarhus, Denmark.
When not desperately trying to understand
mathematics I enjoy the outdoors, volleyball and amateur acting.
NewsPosted by ISB Group Tue, October 17, 2017 13:10:22This autumn, we welcome another new student in our group: Christian Simonsson
My name is
Christian Simonsson and I will be doing my master thesis here in the ISB-group.
I am a 5th year engineering biology student with my master’s profile
being Materials and Sensors in Biomedince. For my master’s thesis I wanted to
do something a bit different from what I have been doing the last two years. Since
my Bachelor’s project was on the topic of systems biology, and since I have an
interest in modeling (in biology and physiology ), I was very pleased when I
was given the opportunity to do my thesis here in the ISB group.
Adiponectin, which is a hormone released by mature
adipocyte has been shown to have an important role in the development of type-2
diabetes. However, the precise underlying mechanisms for the production and
release of such hormones in adipocytes are not fully understood. Therefore, an
ongoing project in the ISB group has been to use mathematical modeling to
describe the exocytosis of white adipocytes to predict adiponectin secretion,
making it possible to quantify the exocytosis and endocytosis rates. An article
on the subject was recently published by William Lövfors et al and in my
project I will make use of the model presented in this article. The goal is to
extend the model to also describe the experimental data for adiponectin
secretion induced through the activation of beta-adrenergic signaling pathways
upon extracellular adrenalin stimulation. Hopefully this might contribute to
creating a more complete framework for understanding the regulation of this
important metabolic hormone.
NewsPosted by ISB Group Tue, October 17, 2017 11:19:21
This autumn, we welcome another new student in our group: Sofie Johansson
Hi! I’m Sofie.
I graduated from medical school spring 2017. A few years ago I did my undergraduate project in another scientific group and subsequently kept working there for a while. I was mainly looking at cardiovascular risk factors among adolescents.
In spite of great supervision I wanted to try another scientific field and have now ended up as a student in the ISB group to work on a project in systems biology. My job at the moment is to build a model of the lactate metabolism in the brain.
NewsPosted by ISB Group Tue, October 17, 2017 11:01:01
This autumn, we welcome another new student in our group: Victor Viberg
Hi, my name is Victor Viberg. I’m studying
biomedical engineering at Linköping University, currently I’m working on my
master thesis in the ISB-group at IMT.
The goal of my project is to create a
model that can explain the metabolic fluxes of a cancer cell and how it differs
from a regular healthy cell. Hopefully this new insight will help in developing
more effective treatments for cancer. The model is based on isotropic labeling
of metabolites, and it is the first time this type of data is available for a
whole human cell. My work will build on the previous work of Nicolas Sundqvist.
NewsPosted by ISB Group Mon, October 16, 2017 15:41:04This autumn, we welcome another new student in our group: Thea Sandqvist
My name is Thea and
I'm here in the ISB Group to do a project in systems biology for my 6th semester in Medicine.
My project is about insulin- and
glucose metabolism in rodents switching between chow- and high fatty based-diets. The project is based on a multi-level-multi-scale model
conducted by former ISB Group-member Niclas Berqqvist. My experimental data
comes from Karin G. Stenkula and her research group in Lund.
Besides spending time at the office I enjoy an occational pain-au-chocolat (or two or five).
NewsPosted by ISB Group Thu, September 21, 2017 09:38:29
This autumn, we welcome a new student in our group: Valentin
Hello! My name is Valentin Kindesjö. I started medical
school at Linköping University in the spring of 2015 after studying a year and
a half of biomedical engineering. For the autumn of 2017, I have found my way
back to IMT to join ISB group for a project in mathematical modelling, where I will
be continuing the work of previous students (most recently Johanna Fridberger
and Thirza Poot) in expanding a multi-level model over the regulation of
glucose, insulin and fatty acids, created by joining a glucose- and insulin
model created by Dalla Man et al and a NEFA model, created by Jelic et al as an
expansion on a model by Fianne Sips. I will be working to make the NEFA part of
this model more physiologically correct. Hopefully, this work will bring us
closer to finding out the exact role played by adipose tissue in maintaining
the systemic energy homeostasis, and shed some light over the dynamic interplay
between the different mechanism involved in the storage and release of fatty
I am spending my autumn in Oxford, at the group of Fredrik
Karpe, professor of metabolic medicine at the Oxford Centre for Diabetes,
Endocrinology and Metabolism, who conducted the experiments where the data I
will be using was collected.
EventsPosted by ISB Group Thu, November 10, 2016 12:03:02
On October 26, 2006 ~ 10 years ago! - Gunnar Cedersund defended his PhD thesis. This was the start of the process of creating the reseach group isbgroup.eu. To celebrate the 10-year mark, we have decided to arrange on January 14th 2017 a reunion party for anyone who has been involved so far!
Location: Linköping (Specifics tbd)
Date: 14th January 2017
If you're interested in the current projects or how your past project has fared, you'll get the chance to catch up during the evening. We are also very interested in the path you've chosen, so if you can, please do join us and tell us what you have been up to since we last saw you in the group. The day will consist of some lectures and general social interactions with the chance to see what has happened with everyone in the day, and a BIG party in the evening.
In case your invitation got lost in the Internet, please contact us at firstname.lastname@example.org to reserve. We hope to see you in Linköping in January!
The reunion committee
PS. Below are some group pictures to help you reminisce.
Gunnar defending his thesis 2006.
ISB group 2010.
ISB group 2012.
ISB group 2015.