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Three new students

NewsPosted by ISB Group Wed, October 05, 2016 16:25:24
During the autumn we have three new students in our group
Nicolas, Fredrik, and Johanna: The latest students to join our group.

Here's their introduction

Nicolas

I’m a student at Linköpings university, studying for a masters of science in engineering biology, I have finished my third year but have decided to take a break to work as an intern at the ISB group.

The project I’m involved with at the moment revolves around studying the regulatory mechanisms that control the antioxidant levels in the body. Antioxidants are generally believed to be unregulated and simply accumulate upon continuous intake and such an accumulation could help explain the many health benefits observed when eating antioxidant rich foods. However this accumulation has never been observed for more than a few hours after intake. The results of previous studies show that there is reason to believe that the antioxidant levels are regulated by homeostasis. The purpose of this project is to use systems biology to investigate the regulatory mechanisms involved with antioxidant metabolism and see if there is a homeostatic regulation of the body's antioxidant capacity. This project will continue and expand upon the project I did for my bachelor thesis in the spring of 2016 where I investigated the regulatory mechanisms that control the antioxidant capacity (AOC) in the cytoplasm and used mathematical modelling and prediction analysis in order try to predict how the AOC levels would change after a single dose of antioxidants are given to a test subject. At my disposal i had access to data collected from experimental studies conducted at Newcastle university. With the results from my bachelors project I was able to provide the team in Newcastle with a decision basis for how to design a new experimental study which they conducted in the summer of 2016. I will use this data, collected from the latest study in Newcastle to continue investigating how antioxidant capacity is regulated and also investigate how different test subjects react differently using nonlinear mixed-effect modelling.


Fredrik

My name is Fredrik Eklund and my background lies in bioengineering, with a focus on materials and biosensors. I’m currently working on my master’s degree thesis in the field of systems biology, however. The project I’m involved in is a continuation of previous students’ work on a statistical heart attack model. It is a predictive model meant to be used as decision support by doctors. In its core, a Bayesian network is trained to understand relationships between a large number of parameters. The trained network is then used on a new patient’s measurements for prediction. Based on the result, a medical practitioner can then take the appropriate course of action.


Johanna
My name is Johanna Fridberger and I am a new member of the ISB group. I will be staying for one semester conducting a project on the model developed by Fianne Sips described in the article ”Model-Based Quantification of the Systemic Interplay between Glucose and Fatty Acids in the Postprandial State” in which I will exchange the current NEFA (Non-Esterified Fatty Acids) part of the model to one that better describes physiological conditions. This is possible thanks to new data on NEFA homeostasis. I am doing the project as part of my education in medicine at Linköping University, now reaching the end of the third year. I have really enjoyed working in this group so far, and I am excited over the next couple of months here!